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硕士生导师简介——高小康
2020-10-30 18:25  药学院

姓名:高小康

职务、职称:副教授

学院:药学院

电子邮箱20160501@hbmu.edu.cn

研究领域:生物色谱及中药活性筛选

学习工作经历:

1999年9月-2003年6月四川大学学习

2003年9月-2006年6月四川大学学习

2012年9月-2015月12月西北大学学习

2016年1月-至今湖北医药学院工作

代表性研究成果

1.科研项目:

(1)固定化β2-肾上腺素受体色谱模型的调控及其在中药活性成分筛选中的应用,湖北医药学院人才启动金项目,2016年主持

(2)β2肾上腺素受体色谱应用于中药活性成分的筛选,十堰市科技局项目-引导性项目,2017年主持

(3)基于Beta2-肾上腺素受体色谱的中药活性成分筛选,湖北省教育厅科技项目-指导性项目,2017年主持

(4)温度调控固定化β2-肾上腺素受体色谱筛选中药材的活性成分,湖北省科技厅省自然科学基金-指导性项目,2018年主持

(5)经典名方散偏汤的开发与应用,十堰市科技局项目--一般项目,2019年主持

(6)经典名方的开发应用,湖北省科技厅中央引导地方科技发展专项,2019年主持

2.期刊论文:

(1)Xiaokang Gao, Lingjian Yang, Yajun Bai, Qian Li, Xinfeng Zhao, Liujiao Bian, Xiaohui Zheng. Screening of bioactive components from traditional Chinese medicine by immobilized β2 adrenergic receptor coupled with high performance liquid chromatography/massspectrometry. Journal of Chromatography B, 1134-1135 (2019) 121782.

(2)Xiaokang Gao, Lingjian Yang, Qian Li, Yuxin An, Sha Liao, Haiyang Gao, Xinfeng Zhao, Liujiao Bian, Xiaohui Zheng. Investigation on temperature-induce conformational change of immobilized β2 adrenergic receptor. Biochemicaland Biophysical Research Communications 494 (2017) 634-640.

(3)Xiaokang Gao, QianLi, Xinfeng Zhao, Jingjing Huang, Liujiao Bian, Jianbin Zheng, Zijian Li, Youyi Zhang, Xiaohui Zheng. Investigationon the Binding of Terazosin Hydrochloride and Naftopidil to an Immobilized α1–Adrenoceptor by Zonal Elution. Chromatographia, 2014, 77: 1235-1239.

(4)Xiaokang Gao, Yunzhe Li, Yu Qin, Enhui Chen, Qian Li, Xinfeng Zhao, Liujiao Bian, Jianbin Zheng, Zijian Li, Youyi Zhang, Xiaohui Zheng. Reversible and oriented immobilization of histidine-tagged protein on silica gel characterized byfrontal analysis. RSC Adv, 2015, 5: 24449-24454.

(5)Qian Li, Liujiao Bian, Xinfeng Zhao, Xiaokang Gao, Jianbin Zheng, Zijian Li, Youyi Zhang, Ru Jiang, Xiaohui Zheng. Immobilised Histidine Tagged β2-Adrenoceptor Oriented by a Diazonium Salt Reaction and Its Application in Exploring Drug-ProteinInteraction Using Ephedrine and Pseudoephedrine as Probes. Plos one, 2014, 9(4): e94955.

(6)Yuxin An, Qian Li, Jiejun Chen, Xiaokang Gao, Hongwei Chen, Chaoni Xiao, Liujiao Bian, Jianbin Zheng, Xinfeng Zhao and Xiaohui Zheng. Binding of caffeic acid to human serumalbumin by the retention data and frontal analysis. Biomedical Chromatography, 2014, 28: 1881-1886.

(7)Qian Li, Jing Wang, Lingjian Yang, Xiaokang Gao, Hongwei Chen, Xinfeng Zhao, Liujiao Bian and Xiaohui Zheng. Estimationof interaction between oriented immobilized green fluorescent protein and itsantibody by high performance affinity chromatography and molecular docking.Journal of Molecular Recognition, 2015, 28: 438-446.

(8)高小康,白蓉,朱峥嵘,郑晓晖.固定化肾上腺素受体色谱模型的建立及表征.湖北医药学院学报,2017,36(1):15-19.

(9)李欧,胡娇,李玉坤,杨娟,李征远,柯威,高小康*.星点设计-效应面法优化黄芩苷两种提取工艺并比较.湖北医药学院学报,2020,39(2):108-118.

(10)魏登峰,邓欣然,华朵,白李涛,高小康*.对中草药美白功效的概述.当代医药丛论,2019,17(9):202-204.

(11)黄晶晶,李倩,高小康,赵新锋,王世祥,郑晓晖.高效液相色谱-电喷雾-飞行时间串联质谱分析泽兰水提物.中草药,2013,44(16).

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