姓名：郝新才

职务、职称：副院长、副教授

学院：药学院

电子邮箱：xincaih@hbmu.edu.cn

研究领域：(1)从传统中草药、微生物等天然药物资源中寻找结构新颖、具有显著生物活性的天然产物，并以此为先导化合物，通过化学结构改造等方法从中发现高效低毒的新药候选化合物，开发出具有自主知识产权的创新药物研究。(2)中药现代化生产关键技术及其产业化研究。

学习工作经历：

2006.08-今湖北医药学院药学院

2017.09-2018.09美国休斯顿大学药学院访问学者。

代表性研究成果：

1.科研项目：

(1)横向课题，珍稀药用植物组织培养，2019/05-2023/12,100万，在研，主持。

(2)横向课题“互联网+”秦巴山区特色药食资源开发推广与利用，2019/01-2022/12,100万，在研，主持。

(3)湖北省江汉流域特色资源保护与利用工程技术中心开放课题，白芨多糖活性片段及温敏原位凝胶的制备，2019/12-2020/12,4万。

(4) 2018年湖北省高校优秀中青年科技创新团队，白藜芦醇生物提取与工业色谱分离技术的研究与应用，T201813，2018/01-2020/12,20万，在研，主持。

(5)横向课题，虎杖综合开发与利用,2016/01-2018/12,100万，结题，主持。

2.期刊论文：

(1)Jing Chen, Li Cheng, Fuqian Wang, Xuanbin Wang, Yonghui Zhang, Xincai Hao. Chemical constituents from Trichosanthescucumeroides. J. Chin. Pharm. Sci.2020,29 (6):431-438.

(2)Fuqian Wang, Jie Jiang, Song Hu, Xincai Hao, You-sheng Cai, Ying Yed, Haoran Ma, Weiguang Sun, Lu Cheng, Chuanqi Huang, Hucheng Zhu, Hong Zhang, Geng Zhang and Yonghui Zhang. Organic ChemistryFrontiers, 2020, 7(7): 953-959.

(3)Shuangshuang Xie, Changxing Qi, Yulin Duan, Xincai Hao, Yi Guo, Mengyi Deng, Yuben Qiao, Zhengyi Shi, Li Tao, Yunfang Cao, Lianghu Gu, Yuan Zhou and Yonghui Zhang. Wilsonglucinols A-C, homoadamantane-type polycyclic polyprenylated acylphloroglucinols withunusual fused epoxy ring skeletons fromHypericumwilsonii. Organic Chemistry Frontiers, 2020, 7(3): 464-471.

(4)Xueyan Duana, Xiaosheng Tan, Lianghu Gu, Junjun Liu, Xincai Hao, Li Tao, Hao Feng, Yunfang Cao, Zhengyi Shi, Yulin Duan,Mengyi Deng, Gang Chen, Changxing Qi, Yonghui Zhang. New secondary metaboliteswith immunosuppressive activity from the phytopathogenic fungus Bipolaris maydis, Bioorganic Chemistry, 2020,99: 103816.

(5)Guanqun Zhana, Rongkun Miao, Fuxin Zhang, Xincai Hao, Xi Zheng, Hui Zhang, Xinxin Zhang, Zengjun Guo. Monoterpene indolealkaloids with diverse skeletons from the stems of Rauvolfia vomitoriaand their acetylcholinesterase inhibitoryactivities. Phytochemistry, 2020, 177: 112450.

(6)Qin Li, Chunmei Chen, Yan He, Mengsha Wei, LiCheng, Xin Kang, Jianping Wang, Xincai Hao(*), Hucheng Zhu(*), Yonghui Zhang(*). Prenylatedquinolinone alkaloids and prenylated isoindolinone alkaloids from the fungus Aspergillus nidulans. Phytochemistry, 2019, 169, 112-177.

(7)Mengting Liu, Weiguang Sun, Ling Shen,Xincai Hao, Weaam Hasan Al Anbari,Shuang Lin, Huaqiang Li, Weixi Gao, Jianping Wang, Zhengxi Hu*,Yonghui Zhang*.BipolaricinsA-I, Ophiobolin-Type Tetracyclic Sesterterpenes from a PhytopathogenicBipolarissp. Fungus.J. Nat. Prod.2019,82, 10,2897-2906.

(8)MengtingLiu, Weiguang Sun, Ling Shen,Xincai Hao, Weaam Hasan Al Anbari, ShuangLin, Huaqiang Li, Weixi Gao, Jianping Wang, Zhengxi Hu, Yonghui Zhang. Bipolaricins A-I, Ophiobolin-Type Tetracyclic Sesterterpenes from a Phytopathogenic Bipolarissp. Fungus. Organic Letters, 2019, 82(10), 2897-2906.

(9)Fengli Li, Shuang Lin, Sitian Zhang,Xincai Hao, XiaoNian Li, Beiye Yang, Junjun Liu, Jianping Wang, Zhengxi Hu,Yonghui Zhang. Alterbrassinoids A-D: Fusicoccane-Derived Diterpenoid Dimers Featuring Different Carbon Skeletons from Alternaria brassicicola, OrganicLetters, 2019, 21(20), 8353-8357.

(10)ChenLi, Lanlan Zheng, Xuening Wang, Zhubing Hu, Yan Zheng, Qinhua Chen, Xincai Hao, Xiao Xiao, Xuanbin Wang, Guodong Wang, Yonghong Zhang. Comprehensiveexpression analysis of Arabidopsis GA2-oxidase genes and their functionalinsights. Plant Science, 2019, 285, 1-13.

(11)Xincai Hao(#), Weiguang Sun(#), Changbin Ke, Fuqian Wang, YongboXue, Zengwei luo, Xuanbin Wang, Jinwen Zhang(*), Yonghui Zhang(*), Anti-inflammatory activities of leaf oil fromCinnamomum subaveniumin vitroandin vivo. BioMed Research International, 2019, vol. 2019, 10 pages.

(12)Li Cheng, Jing Chen, Yan Tan, Fuqian Wang, Xuanbin Wang, Yongbo Xue, Xincai Hao(*), Yonghui Zhang.Chemicalconstituents from Teucrium viscidum.Journal of ChinesePharmaceutical Sciences, 2018, 27(10) , 719-723.

(13)TaoZheng, Xincai Hao, Qibin Wang, LiChen, SiJinandFangBian.Entada phaseoloides extract suppresses hepatic gluconeogenesis via activation of the AMPKsignaling pathway. Journal of Ethnopharmacology, 2016, 193(4), 691-699.

(14)邱婧然,赵永恒,王天帅,郝新才.形成性评价在制药工程拟企业化生产实训中的应用[J].广州化工,2020,8,178-180.

(15)郑涛,陈黎,郝新才,王启斌.中药抗冠状病毒研究进展[J].湖北医药学院学报,2020,1,1-6.

(16)王佰灵,邱婧然,郝新才,戈振凯,赵永恒.整合性实验在中药药剂学教学中的应用[J].广州化工,2020,14,160-161164.

(17)赵艳,王启斌,郝新才,郑涛,陈黎.白及促创面愈合作用研究进展[J].中药材,2020,4,1030-1034.

(18)陶平德,郝新才,陈黎.小连翘的化学成分研究[J].现代中药研究与实践,2018,6,24-27.

(19)郝新才,金明,明东坡,张勇洪,谭艳.酶解法提取虎杖中白藜芦醇苷的工艺研究[J].湖北医药学院学报,2018,4,346-349.

(20)王佰灵,郝新才,戈振凯,邱婧然,张豪,赵永恒.延龄草药材HPLC指纹图谱研究[J].湖北医药学院学报,2018,3,225-229.

(21)王佰灵,张豪,郝新才,戈振凯,邱婧然,赵永恒.头顶一颗珠的药理作用研究进展[J].国际中医中药杂志,2018,5,478-481.

(22)郑兰兰,郝新才,卫荣华,刘丹丹,张勇洪,汪选斌,李琛.植物大环寡肽的生物学活性与药用价值[J].国外医药抗生素分册,2017,6,263-267.

(23)高小康,郝新才,谢勇,郭兴荣.浅析如何教好及学好医学化学[J].新校园(上旬),2016,9,112.